Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53
The mutational landscape of p53 in cancer is unusual among tumor suppressors because most of the alterations are of the missense type and localize to a single domain: the ~220 amino acid DNA-binding domain. Nearly all of these mutations produce the common effect of reducing p53’s ability to in...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI AG
2020-02-01
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| Schriftenreihe: | Biomolecules |
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| Online-Zugang: | https://www.mdpi.com/2218-273X/10/2/303 |
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