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Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection

Current coronavirus disease-19 (COVID-19) vaccines are administered by the intramuscular route, but this vaccine administration failed to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection in the upper respiratory tract, mainly due to the absence of virus-specific m...

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Principais autores: Patricia Pérez, David Astorgano, Guillermo Albericio, Sara Flores, Pedro J. Sánchez-Cordón, Joanna Luczkowiak, Rafael Delgado, José M. Casasnovas, Mariano Esteban, Juan García-Arriaza
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-09-01
Serier:Frontiers in Immunology
Fag:
SARS-CoV-2
vaccine candidates
MVA
S protein
intranasal delivery
immunogenicity
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.995235/full
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