Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition

Osteosarcomas are immune-resistant and metastatic as a result of elevated nonsense-mediated RNA decay (NMD), reactive oxygen species (ROS), and epithelial-to-mesenchymal transition (EMT). Although vitamin D has anti-cancer effects, its effectiveness and mechanism of action against osteosarcomas are...

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Autors principals:	Enrico Capobianco, Vanessa McGaughey, Gerbenn Seraphin, John Heckel, Sandra Rieger, Thomas S. Lisse
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-05-01
Col·lecció:	Frontiers in Oncology
Matèries:	osteosarcoma vitamin D VDR ROS EMT Snai2
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1188641/full
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