Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

Despite exciting developments in cancer immunotherapy, its broad application is limited by the paucity of targetable antigens on the tumor cell surface. As an intrinsic cellular pathway, nonsense-mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harbori...

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Autors principals:	Ashley L Cook, Surojit Sur, Laura Dobbyn, Evangeline Watson, Joshua D Cohen, Blair Ptak, Bum Seok Lee, Suman Paul, Emily Hsiue, Maria Popoli, Bert Vogelstein, Nickolas Papadopoulos, Chetan Bettegowda, Kathy Gabrielson, Shibin Zhou, Kenneth W Kinzler, Nicolas Wyhs
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-02-01
Col·lecció:	eLife
Matèries:	nonsense-mediated decay high-throughput screen next-generation sequencing immunotherapy drug repurposing
Accés en línia:	https://elifesciences.org/articles/95952
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