Engineered probiotic-derived indole-3-propionic acid inhibits ubiquitination via AHR signaling to treat postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) has a high incidence in middle-aged and elderly women, leading to an increased risk of fractures and elevated rates of disability and mortality. In this work, we identified the reduction of indole-3-propionic acid (IPA) as a potential key factor contributing to the...

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Główni autorzy:	Xueli Qiu, Lijun Wu, Fengxian Jiang, Huajian Shan, Lei Sheng, Bo Tian, Heng Wang, Hao Cui, Lide Tao, Chenyang Wu, Yuqian Yao, Chao Wang, Xiaozhong Zhou, Yingzi Zhang, Jinyu Bai
Format:	Artigo
Język:	Inglês
Wydane:	Taylor & Francis Group 2026-12-01
Seria:	Gut Microbes
Hasła przedmiotowe:	Postmenopausal osteoporosis gut microbiota indole-3-propionic acid gut-bone axis engineered probiotic
Dostęp online:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2612620
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