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Endothelial α6β4 integrin protects during experimental autoimmune encephalomyelitis-induced neuroinflammation by maintaining vascular integrity and tight junction protein expression

Abstract Background Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, in...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jennifer V. Welser, Sebok K. Halder, Ravi Kant, Amin Boroujerdi, Richard Milner
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2017-11-01
Rangatū:Journal of Neuroinflammation
Ngā marau:
Urunga tuihono:http://link.springer.com/article/10.1186/s12974-017-0987-2
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