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Endothelial α6β4 integrin protects during experimental autoimmune encephalomyelitis-induced neuroinflammation by maintaining vascular integrity and tight junction protein expression

Abstract Background Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, in...

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Principais autores: Jennifer V. Welser, Sebok K. Halder, Ravi Kant, Amin Boroujerdi, Richard Milner
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-11-01
coleção:Journal of Neuroinflammation
Assuntos:
Endothelial
Extracellular matrix
Laminin
Integrin
Blood-brain barrier
Vascular
Acesso em linha:http://link.springer.com/article/10.1186/s12974-017-0987-2
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