KRT7 promotes pancreatic cancer metastasis by remodeling the extracellular matrix niche through FGF2-fibroblast crosstalk

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with a dismal prognosis due to distant metastasis. Through an analysis of large RNA sequencing and proteomics datasets, we found that high KRT7 expression in PDAC patients was correlated with liver metastasis and poor survival....

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Autors principals:	Yuting Jiang, Chengyu Liao, Jianlin Lai, Yunyi Peng, Qilin Chen, Xiaoling Zheng
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-02-01
Col·lecció:	Scientific Reports
Matèries:	Pancreatic ductal adenocarcinoma Metastasis Extracellular matrix Cancer-associated fibroblasts Fibroblasts
Accés en línia:	https://doi.org/10.1038/s41598-024-84129-1
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