KRT7 promotes pancreatic cancer metastasis by remodeling the extracellular matrix niche through FGF2-fibroblast crosstalk

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with a dismal prognosis due to distant metastasis. Through an analysis of large RNA sequencing and proteomics datasets, we found that high KRT7 expression in PDAC patients was correlated with liver metastasis and poor survival....

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Bibliografiset tiedot

Päätekijät:	Yuting Jiang, Chengyu Liao, Jianlin Lai, Yunyi Peng, Qilin Chen, Xiaoling Zheng
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2025-02-01
Sarja:	Scientific Reports
Aiheet:	Pancreatic ductal adenocarcinoma Metastasis Extracellular matrix Cancer-associated fibroblasts Fibroblasts
Linkit:	https://doi.org/10.1038/s41598-024-84129-1
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