A cell line–derived, immune-competent neurospheroid model to study neuroinflammation and human brain disorders

IntroductionThree-dimensional (3D) human brain models have become indispensable tools to investigate neuroimmune interactions and inflammatory processes in the human central nervous system in vitro. Nevertheless, existing models, including brain organoids and other iPSC-derived systems, are often co...

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Autori principali:	Alexandro Angelo Bufi, Andrea Papait, Serafina Farigu, Elsa Vertua, Patrizia Bonassi Signoroni, Elisa Scalvini, Elisabetta Giuzzi, Alice Paini, Paola Chiodelli, Antonietta Rosa Silini, Peter Ponsaerts, Ornella Parolini
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	3D model cell lines drug screening hypoxia microglia neuroinflammation
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1792896/full
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