Potency-enhancing mutations in E3-19K and i-leader increase the cytolytic activity of the PH20/SPAM1-armed oncolytic adenovirus Ad5Δ24RGD

The oncolytic adenovirus Ad5-delta-24-RGD (Ad5Δ24RGD) exhibits suboptimal therapeutic efficacy in high-grade glioma. Here, we show that combining two specific potency-enhancing mutations in E3-19K and i-leader (designated 19KSS-iLQ125Ter) markedly increases the cytolytic efficiency and the size of v...

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Autori principali:	Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia A. Vasiukova, Marat P. Valikhov, Anastasia A. Chernysheva, Gaukhar M. Yusubalieva, Vladimir P. Chekhonin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Molecular Therapy: Oncology
Soggetti:	MT: Regular Issue adenovirus death protein E3-19K glioblastoma hyaluronidase PH20 i-leader
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2950329926000135
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