Potency-enhancing mutations in E3-19K and i-leader increase the cytolytic activity of the PH20/SPAM1-armed oncolytic adenovirus Ad5Δ24RGD

The oncolytic adenovirus Ad5-delta-24-RGD (Ad5Δ24RGD) exhibits suboptimal therapeutic efficacy in high-grade glioma. Here, we show that combining two specific potency-enhancing mutations in E3-19K and i-leader (designated 19KSS-iLQ125Ter) markedly increases the cytolytic efficiency and the size of v...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia A. Vasiukova, Marat P. Valikhov, Anastasia A. Chernysheva, Gaukhar M. Yusubalieva, Vladimir P. Chekhonin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-03-01
Edice:	Molecular Therapy: Oncology
Témata:	MT: Regular Issue adenovirus death protein E3-19K glioblastoma hyaluronidase PH20 i-leader
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2950329926000135
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!