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Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci

Abstract Background Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these genetic loci affect regulatory regions, making the interpretation challenging. Chromatin conformation has a fundamental role in gene regulation and...

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Hlavní autoři: Chenfu Shi, Danyun Zhao, Jake Butler, Antonios Frantzeskos, Stefano Rossi, James Ding, Carlo Ferrazzano, Charlotte Wynn, Ryan Malcolm Hum, Ellie Richards, Muskan Gupta, Khadijah Patel, Chuan Fu Yap, Darren Plant, Richard Grencis, Paul Martin, Antony Adamson, Stephen Eyre, John Bowes, Anne Barton, Pauline Ho, Magnus Rattray, Gisela Orozco
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2025-02-01
Edice:Genome Biology
Témata:
Chromatin conformation
Hi-C
Inflammatory diseases
Gene regulation
GWAS
QTLs
On-line přístup:https://doi.org/10.1186/s13059-025-03492-y
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