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Case Report: Co-existence of BCR::PDGFRA gene fusion and PDGFRA variants in myeloid neoplasm with persistent leukocytosis, large splenomegaly, and eosinophilia

Persistent leukocytosis, massive splenomegaly, and eosinophilia are common manifestations in patients with myeloproliferative neoplasms (MPNs), particularly in those with chronic myeloid leukemia (CML). CML is characterized by the BCR::ABL fusion gene, typically associated with the t(9;22)(q34;q11)...

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Autori principali: Zhifang Xiao, Chongyan Lu, Peng Zhang, Na Han, Xianjun He, Jinfeng Zhang, Yueqi Feng, Mengshan Guan, Ling Ouyang, Yang Gao, Yonghua Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-02-01
Serie:Frontiers in Oncology
Soggetti:
BCR::PDGFRA fusion
imatinib
myeloproliferative neoplasm
PDGFRA variants
tyrosine kinase inhibitors
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2026.1671293/full
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