Case Report: Co-existence of BCR::PDGFRA gene fusion and PDGFRA variants in myeloid neoplasm with persistent leukocytosis, large splenomegaly, and eosinophilia

Persistent leukocytosis, massive splenomegaly, and eosinophilia are common manifestations in patients with myeloproliferative neoplasms (MPNs), particularly in those with chronic myeloid leukemia (CML). CML is characterized by the BCR::ABL fusion gene, typically associated with the t(9;22)(q34;q11)...

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Hlavní autoři:	Zhifang Xiao, Chongyan Lu, Peng Zhang, Na Han, Xianjun He, Jinfeng Zhang, Yueqi Feng, Mengshan Guan, Ling Ouyang, Yang Gao, Yonghua Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-02-01
Edice:	Frontiers in Oncology
Témata:	BCR::PDGFRA fusion imatinib myeloproliferative neoplasm PDGFRA variants tyrosine kinase inhibitors
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1671293/full
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