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Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by the highest mortality among carcinomas. The pathogenesis of PDAC requires elevated autophagy, inhibition of which using hydroxychloroquine has shown promise. However, current realization is impeded by its suboptimal use and unpredictable to...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Ningna Weng, Siyuan Qin, Jiayang Liu, Xing Huang, Jingwen Jiang, Li Zhou, Zhe Zhang, Na Xie, Kui Wang, Ping Jin, Maochao Luo, Liyuan Peng, Edouard C. Nice, Ajay Goel, Suxia Han, Canhua Huang, Qing Zhu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2022-07-01
Rangatū:Acta Pharmaceutica Sinica B
Ngā marau:
Econazole
Autophagy
PDAC
ATF3
AKT
Organoid
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S221138352200048X
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