Structure-guided development of an electrochemical aptasensor for Salmonella Typhi HlyE antigen detection using in silico and experimental approaches

Abstract Efficient and timely detection of biomarkers for typhoid fever is pivotal for improving treatment outcomes and preventing further transmission of the disease. This study addresses the pressing need for a rapid and accurate point-of-care test to detect Salmonella Typhi HlyE antigen, a vital...

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Autori principali:	Mohamad Ahmad Najib, Anja Winter, Khairul Mohd Fadzli Mustaffa, Muhammad Hafiznur Yunus, Eugene Boon Beng Ong, Kasturi Selvam, Muhammad Fazli Khalid, Mohd Syafiq Awang, Asrulnizam Abd Manaf, Yazmin Bustami, Habibah A. Wahab, Ismail Aziah
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	Scientific Reports
Soggetti:	Aptamer Molecular docking Molecular dynamics Aptasensor Salmonella Typhi
Accesso online:	https://doi.org/10.1038/s41598-026-38666-6
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