The delivery challenge of adeno-associated virus vector-based gene therapies for neurological diseases

There is great anticipation that gene therapies can offer solutions to many neurological diseases. Already, much is known about therapeutic targets and how they would need to be manipulated to mitigate disease. For such gene therapies to move to the clinic, potent CNS delivery vehicles are needed. O...

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Principais autores:	Alissa Pak, Darcy Wear, Nareh Tahmasian, Jung Yeon Min, Davina Premraj, Rachel Gibbs, Kiah Spencer, Susanna Fang, Thomas Zerbes, Medha Krishnan, Zahra Nasser, Gerold Schmitt-Ulms
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-02-01
coleção:	Frontiers in Neuroscience
Assuntos:	adeno-associated virus (AAV) capsid gene therapy (GT) neurodegenerative diseases neurological disease
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1768545/full
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