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Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool

Abstract Embryonic hematopoietic stem and progenitor cells (HSPCs) have the clinically valuable ability to undergo substantial proliferative expansion while maintaining multipotency, which remains difficult to replicate in culture. Here, we show that newly specified HSPCs achieve this unique state b...

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Príomhchruthaitheoirí: Eleanor Meader, Morgan T. Walcheck, Mindy R. Leder, Patrice Delaney, Marcelo Falchetti, Ran Jing, Christopher Li, Netra K. Kambli, Paul J. Wrighton, Wade W. Sugden, Mohamad A. Najia, Isaac M. Oderberg, Vivian M. Taylor, Zachary C. LeBlanc, Eleanor D. Quenzer, Sung-Eun Lim, Thorsten Schlaeger, George Q. Daley, Wolfram Goessling, Trista E. North
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2026-02-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-026-69593-9
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