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Quick, Coordinated and Authentic Reprogramming of Ribosome Biogenesis during iPSC Reprogramming

Induction of pluripotent stem cells (iPSC) by OCT4 (octamer-binding transcription factor 4), SOX2 (SR box 2), KLF4 (Krüppel-Like Factor 4), and MYC (cellular Myelocytomatosis, c-MYC or MYC) (collectively OSKM) is revolutionary, but very inefficient, slow, and stochastic. It is unknown as to what und...

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Hovedforfatter: Kejin Hu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-11-01
Serier:Cells
Fag:
ribosome biogenesis
mesenchymal-to-epithelial transition (MET)
fibroblasts
human embryonic stem cell (ESC)
reprogramome
reprogramming legitimacy
Online adgang:https://www.mdpi.com/2073-4409/9/11/2484
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