High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression

Engineered chromodomains are promising probes to analyze histone methylation. Here the authors designed high-affinity chromodomains for enhanced genome-wide binding analysis, live-cell imaging and ultra-potent CRISPR-based gene repression.

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	G. Veggiani, R. Villaseñor, G. D. Martyn, J. Q. Tang, W. M. Krone, J. Gu, C. Chen, M. L. Waters, K. H. Pearce, T. Baubec, S. S. Sidhu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2022-11-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-022-34269-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!