High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression

Engineered chromodomains are promising probes to analyze histone methylation. Here the authors designed high-affinity chromodomains for enhanced genome-wide binding analysis, live-cell imaging and ultra-potent CRISPR-based gene repression.

Detalles Bibliográficos

Principais autores:	G. Veggiani, R. Villaseñor, G. D. Martyn, J. Q. Tang, W. M. Krone, J. Gu, C. Chen, M. L. Waters, K. H. Pearce, T. Baubec, S. S. Sidhu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2022-11-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-022-34269-7
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