decompTumor2Sig: identification of mutational signatures active in individual tumors

Abstract Background The somatic mutations found in a tumor have in most cases been caused by multiple mutational processes such as those related to extrinsic carcinogens like cigarette smoke, and those related to intrinsic processes like age-related spontaneous deamination of 5-methylcytosine. The e...

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Autors principals:	Sandra Krüger, Rosario M. Piro
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-04-01
Col·lecció:	BMC Bioinformatics
Matèries:	Somatic mutations Mutational processes Mutational signatures Signature refitting Decomposition of tumor genomes
Accés en línia:	http://link.springer.com/article/10.1186/s12859-019-2688-6
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