Enhancement of HSA-pFSHβ production by disrupting YPS1 and supplementing N-acetyl-L-cysteine in Pichia pastoris

IntroductionPichia pastoris is widely used for the production of recombinant proteins, but the low production efficiency hinders its wide application in biopharmaceuticals. Moreover, many biopharmaceutical-like proteins are accompanied by degradation during secretory expression in P. pastoris.Object...

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Hlavní autoři:	Gang Luo, Zijian Geng, Buayisham Kuerban, Yingqing Xu, Jingjing Yang, Jiying Liu, Muwang Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-12-01
Edice:	Frontiers in Microbiology
Témata:	Pichia pastoris follicle-stimulating hormone YPS1 NAC YPT7
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.998647/full
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