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Plakoglobin transmits tension across VE-cadherin for vascular leak formation and leukocyte diapedesis

Abstract VE-cadherin controls endothelial junction integrity, and thereby inflammation-induced vascular permeability and leukocyte extravasation. The adhesive function of VE-cadherin is influenced by its binding to β-catenin, which is linked by α-catenin to actin. Plakoglobin can replace β-catenin i...

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Detalles Bibliográficos
Principais autores: Neha Uttekar, Annette Artz, Vallari Ghanekar, Pragya Kaul, Jessica Heinrichs, Rebekka I Stegmeyer, Gizem Gülevin Takir, Astrid F Nottebaum, Dietmar Vestweber
Formato: Artigo
Idioma:Inglês
Publicado: Springer Nature 2026-03-01
Series:The EMBO Journal
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Acceso en liña:https://doi.org/10.1038/s44318-026-00732-0
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