Plakoglobin transmits tension across VE-cadherin for vascular leak formation and leukocyte diapedesis
Abstract VE-cadherin controls endothelial junction integrity, and thereby inflammation-induced vascular permeability and leukocyte extravasation. The adhesive function of VE-cadherin is influenced by its binding to β-catenin, which is linked by α-catenin to actin. Plakoglobin can replace β-catenin i...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Nature
2026-03-01
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| Series: | The EMBO Journal |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1038/s44318-026-00732-0 |
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