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Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme

CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance to treatment eventually occurs through the ac...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula, Yogish Kumar Honnavalli
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-03-01
Schriftenreihe:Molecules
Schlagworte:
dual inhibitor
CDK4/6
aromatase
structure-based pharmacophore
molecular docking
MD simulations
Online-Zugang:https://www.mdpi.com/1420-3049/28/6/2490
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