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Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface

Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation. Our structural knowledge on how Vif and A3G interact is limited, beca...

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Principais autores: Michael Letko, Thijs Booiman, Neeltje Kootstra, Viviana Simon, Marcel Ooms
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015-12-01
Series:Cell Reports
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124715012577
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