Inhibition of Xanthine Oxidase by Pyrazolone Derivatives Bearing a 4-(Furan-2-yl)benzoic Acid Moiety

The pyrazolone-based 4-(furan-2-yl)benzoic acids have been synthesized and studied as xanthine oxidase inhibitors. This enzyme is one of the therapeutic targets for the treatment of hyperuricemia and related diseases. The compounds studied have found to exhibit low micromolar IC50 values relative to...

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Hlavní autoři:	Alona V. Beiko, Oleksandr L. Kobzar, Maryna V. Kachaeva, Stepan G. Pilyo, Vsevolod Yu. Tanchuk, Andriy I. Vovk
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National University of Pharmacy (Kharkiv) 2023-12-01
Edice:	Журнал органічної та фармацевтичної хімії
Témata:	xanthine oxidase inhibition pyrazolone benzoic acid molecular docking molecular dynamics
On-line přístup:	https://ophcj.nuph.edu.ua/article/view/298726
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