Inhibition of Xanthine Oxidase by Pyrazolone Derivatives Bearing a 4-(Furan-2-yl)benzoic Acid Moiety

The pyrazolone-based 4-(furan-2-yl)benzoic acids have been synthesized and studied as xanthine oxidase inhibitors. This enzyme is one of the therapeutic targets for the treatment of hyperuricemia and related diseases. The compounds studied have found to exhibit low micromolar IC50 values relative to...

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Prif Awduron:	Alona V. Beiko, Oleksandr L. Kobzar, Maryna V. Kachaeva, Stepan G. Pilyo, Vsevolod Yu. Tanchuk, Andriy I. Vovk
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National University of Pharmacy (Kharkiv) 2023-12-01
Cyfres:	Журнал органічної та фармацевтичної хімії
Pynciau:	xanthine oxidase inhibition pyrazolone benzoic acid molecular docking molecular dynamics
Mynediad Ar-lein:	https://ophcj.nuph.edu.ua/article/view/298726
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!