Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers who received a single dose of ambrisentan, atorva...

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主要な著者:	Miriam Saiz-Rodríguez, Susana Almenara, Marcos Navares-Gómez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, María Santos, Gina Mejía, Alberto M. Borobia, Cristina Rodríguez-Antona, Francisco Abad-Santos
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-04-01
シリーズ:	Biomedicines
主題:	CYP3A4 CYP3A5 pharmacokinetics
オンライン･アクセス:	https://www.mdpi.com/2227-9059/8/4/94
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