The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

Abstract Background The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57kip2 expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-...

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Hauptverfasser:	Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini, Rossella Maione
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-01-01
Schriftenreihe:	Epigenetics & Chromatin
Schlagworte:	p57kip2/Cdkn1c Kcnq1ot1 Muscle differentiation MyoD H3K27me3 Imprinting
Online-Zugang:	http://link.springer.com/article/10.1186/s13072-019-0253-1
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