Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disease associated with metabolic comorbidities. Microvascular dysfunction has been proposed to drive HFpEF, likely via endothelial cell (EC) dysfunction, yet the role of the mural cells herein has...

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Autori principali:	Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-02-01
Serie:	Cardiovascular Diabetology
Soggetti:	Pericytes Smooth muscle cells Endothelial cells HFpEF Diastolic dysfunction
Accesso online:	https://doi.org/10.1186/s12933-025-02623-w
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