Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate

The proteome of Plasmodium falciparum exhibits a marked propensity for aggregation. This characteristic results from the parasite’s AT-rich genome, which encodes numerous proteins with long asparagine-rich stretches and low structural complexity, which lead to abundant intrinsically disordered regio...

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Hlavní autoři:	Yunuen Avalos-Padilla, Inés Bouzón-Arnáiz, Miriam Ramírez, Claudia Camarero-Hoyos, Marc Orozco-Quer, Elsa M. Arce, Diego Muñoz-Torrero, Xavier Fernàndez-Busquets
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-05-01
Edice:	Frontiers in Cellular and Infection Microbiology
Témata:	Plasmodium falciparum E3 ubiquitin ligases proteostasis disruption protein aggregation new antimalarial therapies
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1565814/full
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