Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense

Summary: Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with previously undescribed contributions to IFN-mediat...

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Autori principali:	Sonja Fernbach, Eva E. Spieler, Idoia Busnadiego, Umut Karakus, Anouk Lkharrazi, Silke Stertz, Benjamin G. Hale
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2022-03-01
Serie:	Cell Reports
Soggetti:	CP: Microbiology CP: Immunology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221112472200290X
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