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Sex differences in the polygenic architecture of hearing problems in adults

Abstract Background Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP bio...

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Asıl Yazarlar: Flavio De Angelis, Oana A. Zeleznik, Frank R. Wendt, Gita A. Pathak, Daniel S. Tylee, Antonella De Lillo, Dora Koller, Brenda Cabrera-Mendoza, Royce E. Clifford, Adam X. Maihofer, Caroline M. Nievergelt, Gary C. Curhan, Sharon G. Curhan, Renato Polimanti
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2023-05-01
Seri Bilgileri:Genome Medicine
Konular:
Hearing problems
Genome-wide association study
Ancestry; Polygenic risk scores
Transcriptomic regulation
Sex differences
Pleiotropy
Online Erişim:https://doi.org/10.1186/s13073-023-01186-3
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