Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer

Abstract Triple negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer, whose high frequency of relapse is often due to resistance to chemotherapy. Here, we identify inosine monophosphate dehydrogenase 2 (IMPDH2) as a contributor to doxorubicin resistance, in multiple TNBC m...

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Detalhes bibliográficos

Principais autores:	Tatiane da Silva Fernandes, Bryan M. Gillard, Tao Dai, Jeffrey C. Martin, Kanita A. Chaudhry, Scott M. Dugas, Alyssa A. Fisher, Pia Sharma, RongRong Wu, Kristopher M. Attwood, Subhamoy Dasgupta, Kazuaki Takabe, Spencer R. Rosario, Anna Bianchi-Smiraglia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-01-01
coleção:	Scientific Reports
Assuntos:	TNBC Chemo-resistance Doxorubicin Paclitaxel IMPDH2 GTP metabolism
Acesso em linha:	https://doi.org/10.1038/s41598-024-85094-5
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