Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation. p53 is the most frequently mutated gene in human cancers. Li-Fraumeni syndrome patients inheriting...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Life Science Alliance LLC
2021-03-01
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| coleção: | Life Science Alliance |
| Acesso em linha: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000952 |
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