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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 remains a major burden on health resources worldwide. Co...

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Autori principali: Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2023-03-01
Serie:Molecules
Soggetti:
HIV-1
reverse transcriptase
fragment-based drug design
drug discovery
non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Accesso online:https://www.mdpi.com/1420-3049/28/7/3103
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