Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage

Abstract The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired brain and skull growth. Often, faulty centrosomes cause microcephaly, yet aberrant cilia may also be involved. Here, we show using a combination of approaches in human...

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Bibliografiske detaljer

Principais autores:	Martin D. Burkhalter, Tom Stiff, Lars D. Maerz, Teresa Casar Tena, Heike Wiese, Julian Gerhards, Steffen A. Sailer, Linh Anna Trúc Vu, Max Duong Phu, Cornelia Donow, Marius Alupei, Sebastian Iben, Marco Groth, Sebastian Wiese, Joseph A. Church, Penelope A. Jeggo, Melanie Philipp
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2024-09-01
Serier:	Cell Death and Disease
Online adgang:	https://doi.org/10.1038/s41419-024-07042-5
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