Updated Erdman reveals tandem repeat copy number is phase-variable and impacts M. tuberculosis adaptation across evolutionary timescales

ABSTRACT High-quality reference genomes are essential for comparative genomics and accurate genotype-phenotype mapping. Here, we corrected the Mycobacterium tuberculosis Erdman strain reference genome (ErdmanTI) using ultra-deep HiFi sequencing. Among the small variants (n = 275) between ErdmanTI an...

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Auteurs principaux:	Samuel J. Modlin, Nachiket Thosar, Paulina M. Mejía-Ponce, Raegan L. Lunceford, Gaelle Guiewi Makafe, Brian Weinrick, Faramarz Valafar
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2026-01-01
Collection:	mSystems
Sujets:	Mycobacterium tuberculosis phase variation tandem repeat copy number stress adaptation evolution
Accès en ligne:	https://journals.asm.org/doi/10.1128/msystems.01026-25
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