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Updated Erdman reveals tandem repeat copy number is phase-variable and impacts M. tuberculosis adaptation across evolutionary timescales

ABSTRACT High-quality reference genomes are essential for comparative genomics and accurate genotype-phenotype mapping. Here, we corrected the Mycobacterium tuberculosis Erdman strain reference genome (ErdmanTI) using ultra-deep HiFi sequencing. Among the small variants (n = 275) between ErdmanTI an...

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Principais autores: Samuel J. Modlin, Nachiket Thosar, Paulina M. Mejía-Ponce, Raegan L. Lunceford, Gaelle Guiewi Makafe, Brian Weinrick, Faramarz Valafar
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2026-01-01
סדרה:mSystems
נושאים:
Mycobacterium tuberculosis
phase variation
tandem repeat
copy number
stress adaptation
evolution
גישה מקוונת:https://journals.asm.org/doi/10.1128/msystems.01026-25
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