Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload

Abstract Background Follicle development is a complicated biological process that produces mature oocytes, and requires nutrients, growth factors, and steroids produced by ovarian granulosa cells (GCs). High fork head box J2 (FOXJ2) expression might negatively regulate ovarian function; however, the...

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Detalhes bibliográficos

Principais autores:	Yunxia Zhang, Qiqian Wu, Furong Bai, Yanqin Hu, Bufang Xu, Yujie Tang, Jingwen Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-04-01
coleção:	Journal of Ovarian Research
Assuntos:	Follicle development Granulosa cells Apoptosis Mitochondrial calcium overload FOXJ2 MCU
Acesso em linha:	https://doi.org/10.1186/s13048-025-01651-0
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