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DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer

DHOK (14,15β-dihydroxyklaineanone) is a novel diterpene isolated from roots of Eurycoma longifolia Jack, a traditional herb widely applied in Southeast Asia. It is reported that DHOK has cytotoxic effect on cancer cells, but its anti-cancer mechanism has still been not clear. In our study, we first...

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Main Authors: Yuhan Shu, Xin Sun, Guiqin Ye, Mengting Xu, Zhipan Wu, Caixia Wu, Shouxin Li, Jingkui Tian, Haote Han, Jianbin Zhang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DHOK
transcriptome sequencing
autophagy
colorectal cancer
mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.760022/full
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