SIRT1-Mediated Redox and Senescence Regulation in Cancer: Mechanisms and Therapeutic Implications
Silent information regulator type 1 (SIRT1), a NAD<sup>+</sup>-dependent deacetylase, is a central regulator of cancer cell adaptation to oxidative stress and senescence. By deacetylating redox-sensitive transcription factors, such as p53, FOXOs, PGC-1α, and NF-κB, SIRT1 suppresses apoptosis, delays...
שמור ב:
| Principais autores: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
MDPI AG
2025-09-01
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| סדרה: | Antioxidants |
| נושאים: | |
| גישה מקוונת: | https://www.mdpi.com/2076-3921/14/9/1076 |
| תגים: |
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