SIRT1-Mediated Redox and Senescence Regulation in Cancer: Mechanisms and Therapeutic Implications

Silent information regulator type 1 (SIRT1), a NAD⁺-dependent deacetylase, is a central regulator of cancer cell adaptation to oxidative stress and senescence. By deacetylating redox-sensitive transcription factors, such as p53, FOXOs, PGC-1α, and NF-κB, SIRT1 suppresses apoptosis, delays...

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Egile Nagusiak:	Yejin Son, Minyeong Han, Xuefeng Wu, Yoon-Seok Roh
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2025-09-01
Saila:	Antioxidants
Gaiak:	SIRT1 redox signaling cellular senescence reactive oxygen species cancer therapy
Sarrera elektronikoa:	https://www.mdpi.com/2076-3921/14/9/1076
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