Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Abstract Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates....

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Fauzia Nasim, Diethart Schmid, Gergely Szakács, Azmat Sohail, Harald H. Sitte, Peter Chiba, Thomas Stockner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2020-04-01
Schriftenreihe:	Pharmacology Research & Perspectives
Schlagworte:	ABC transporter ABCB1 functional biology multidrug transporter outer gates P‐glycoprotein
Online-Zugang:	https://doi.org/10.1002/prp2.572
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!