Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo

Abstract Background Cryptococcus neoformans (Cn) causes life-threatening meningoencephalitis in individuals with AIDS. Cn’s polysaccharide capsule is mainly composed of glucuronoxylomannan (GXM) and plays a key role in the dysregulation of immunity, resistance to antifungal drugs, and systemic disse...

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Autori principali:	Vanessa Enriquez, Melissa E. Munzen, Luz M. Porras, Claudia L. Charles-Niño, Fahong Yu, Karina Alviña, Raddy L. Ramos, Michael R. Dores, Paola Giusti-Rodriguez, Luis R. Martinez
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-03-01
Serie:	Journal of Neuroinflammation
Soggetti:	C. neoformans Cryptococcoma Meningoencephalitis Microglia Phagocytosis
Accesso online:	https://doi.org/10.1186/s12974-025-03384-9
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