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Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease

The gut microbiota exerts broad control over host physiology through tightly coordinated metabolic networks. Among these, bile salt hydrolase (BSH), a microbial enzyme, serves as a key mediator of microbiota–host crosstalk. As a key upstream gateway reaction in bile acid metabolism, BSH hydrolyzes c...

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Principais autores: Haitao Chu, Xin Song, Chang Liu, Tianjiao Ma, Wanlin Cui
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Immunology
Fag:
bile acid metabolism
BSH
digestive diseases
gut microbiota
gut–liver axis
microbiota-based therapy
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1870619/full
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