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Inhibition of DDR1‐BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer

Abstract The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. Here, we show that nilotinib, a clinically approved drug for chronic myeloid leukaemia, strongly inhibits human CRC cell invasion in vitro and reduces their metastatic potential in intrasplenic tumour mou...

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Príomhchruthaitheoirí: Maya Jeitany, Cédric Leroy, Priscillia Tosti, Marie Lafitte, Jordy Le Guet, Valérie Simon, Debora Bonenfant, Bruno Robert, Fanny Grillet, Caroline Mollevi, Safia El Messaoudi, Amaëlle Otandault, Lucile Canterel‐Thouennon, Muriel Busson, Alain R Thierry, Pierre Martineau, Julie Pannequin, Serge Roche, Audrey Sirvent
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Springer Nature 2018-02-01
Sraith:EMBO Molecular Medicine
Ábhair:
collagen receptor
colorectal cancer
invasion
targeted therapy
tyrosine kinase
Rochtain ar líne:https://doi.org/10.15252/emmm.201707918
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