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Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction

The phosphoprotein Dishevelled (Dvl) is a common essential component of Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. However, the regulation and significance of Dvl phosphorylation are not fully understood. Here, we show that homeodomain-interacting protein kinase 2 (Hipk2) f...

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Autori principali: Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya, Tohru Ishitani
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014-09-01
Serie:Cell Reports
Accesso online:http://www.sciencedirect.com/science/article/pii/S221112471400624X
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